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Τρίτη 18 Ιουλίου 2017

Dendritic Cell Lineage Potential in Human Early Hematopoietic Progenitors

Publication date: 18 July 2017
Source:Cell Reports, Volume 20, Issue 3
Author(s): Julie Helft, Fernando Anjos-Afonso, Annemarthe G. van der Veen, Probir Chakravarty, Dominique Bonnet, Caetano Reis e Sousa
Conventional dendritic cells (cDCs) are thought to descend from a DC precursor downstream of the common myeloid progenitor (CMP). However, a mouse lymphoid-primed multipotent progenitor has been shown to generate cDCs following a DC-specific developmental pathway independent of monocyte and granulocyte poiesis. Similarly, here we show that, in humans, a large fraction of multipotent lymphoid early progenitors (MLPs) gives rise to cDCs, in particular the subset known as cDC1, identified by co-expression of DNGR-1 (CLEC9A) and CD141 (BDCA-3). Single-cell analysis indicates that over one-third of MLPs have the potential to efficiently generate cDCs. cDC1s generated from CMPs or MLPs do not exhibit differences in transcriptome or phenotype. These results demonstrate an early imprinting of the cDC lineage in human hematopoiesis and highlight the plasticity of developmental pathways giving rise to human DCs.

Graphical abstract

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Teaser

Dendritic cells (DCs) are thought to descend from a DC precursor downstream of the common myeloid progenitor (CMP). Helft et al. show that multipotent lymphoid progenitors (MLPs) in humans are more efficient producers of CD141+DNGR-1+ cDC1s than CMPs. Therefore, DC lineage imprinting can occur in early hematopoietic progenitors in humans.


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