Transforming growth factor beta1 (TGF- β1) plays a significant role in craniofacial development. Previous linkage studies reported that the TGF-β1-locus at 19q13.1 harbour predisposing genes for non-syndromic oral clefts. In the present study case parents triads were evaluated to find the transmission effects of genetic variants in TGF - β1 towards non-syndromic cleft lip or palate (NSCL/P). (Source: International Journal of Pediatric Otorhinolaryngology)
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Transmission analysis of TGFB1 gene polymorphisms in non-syndromic cleft lip with or without cleft palate
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