GSE83647 Aneuploidy triggers an immune response

Contributors : Stefano Santaguida ; Amelia Richardson ; Divya Iyer ; Ons M'Saad ; Lauren Zasadil ; Kristin Knouse ; Yao Wong ; Nick Rhind ; Arshad Desai ; Angelika AmonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Changes in chromosome copy number have been proposed to drive disease by modulating the dosage of cancer driver genes and by promoting cancer genome evolution. Given the potential of cells with abnormal karyotypes to become cancerous, do pathways exist that limit the prevalence of such cells? By investigating the immediate consequences of aneuploidy on cell physiology, we identified mechanisms that eliminate aneuploid cells. We find that chromosome mis-segregation leads t...

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