Response to letter to the editor

We thank the authors for their interest in our article.1 We also believe that the combined IV thrombolysis plus stent retriever thrombectomy approach might show a different association between thrombus density and recanalization outcomes than stent retriever thrombectomy alone, which was the focus of our paper. These two distinct groups of patients (thrombectomy with or without preceding administration of IV recombinant tissue plasminogen activator (rtPA)) should be studied separately, as both treatments are now widely applied to modern practice.

We argue that IA administration of rtPA during IA thrombectomy is rather uncommon. For example, early postmarket experience with the Solitaire FR device showed that IA administration of rtPA was used in only 9% of all stent retriever thrombectomy cases.2

We agree that a CT slice thickness of ≤2.5 mm is better than a 5 mm slice for calculating accurate thrombus density. Unfortunately, at present, most clinical centers...

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