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Κυριακή 15 Αυγούστου 2021

Quantification of endolymphatic hydrops and its correlation with Meniere’s disease clinical features

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Abstract

Objective

We aimed to quantitatively evaluate the degree of endolymphatic hydrops and its correlation with the clinical features of Meniere's disease.

Methods

We retrospectively collected data from patients with Meniere's disease who underwent gadolinium-enhanced magnetic resonance imaging (MRI) at our department from January 2018 to December 2019. Mimics software was used to perform three-dimensional modeling of the labyrinth, and volume information was obtained to calculate the endolymphatic hydrops index (EHI). A correlation analysis was conducted with data from pure tone audiometry, electrocochleography (EchoG), vestibular myogenic-evoked potential (VEMP) testing, caloric testing and video head impulse testing (vHIT). A two-dimensional method was also employed to calculate the hydrops ratio(HR) of cochlea and vestibule. The test-retest reliability of EHI /HR from different operators was evaluated.

Results

A total of 23 affected ears were examined, the endolymphatic hydrops index was significantly correlated with Meniere's disease stage, low-frequency hearing threshold, EchoG summating potential/action potential ratio (−SP/AP), and VEMP binaural asymmetry ratio, but no significant correlation was observed between endolymphatic hydrops index and the caloric test or vHIT. The Intraclass correlation coefficient (ICC) of EHI data calculated by two otologists was 0.946(p< 0.001). And the ICC of cochlea and vestibule Hydrops Ratio were 0.844 and 0.832(p< 0.001).

Conclusion

Mimics software can be used to quantitatively evaluate the degree of endolymphatic hydrops and have shown higher test-retest reliability than traditional two-dimensional evaluation method. Endolymphatic hydrops correlates with clinical data, such as Meniere's disease stage, low-frequency hearing threshold, EchoG, and VEMP asymmetry ratio.

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

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