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Κυριακή 28 Φεβρουαρίου 2021

Sorafenib and Lenvatinib Treatment for Metastasis/Recurrence of Radioactive Iodine-refractory Differentiated Thyroid Carcinoma

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In Vivo. 2021 Mar-Apr;35(2):1057-1064. doi: 10.21873/invivo.12350.

ABSTRACT

BACKGROUND/AIM: Radioactive iodine-refractory differentiated thyroid carcinoma (RR-DTC) has been treated with multi-kinase inhibitors (MKIs), e.g., sorafenib (SOR) and lenvatinib (LEN). We analyzed the outcomes of RR-DTC patients who underwent SOR or LEN treatment at Kuma Hospital.

PATIENTS AND METHODS: We enrolled 21 and 18 patients treated with SOR and LEN, respectively.

RESULTS: The incidence of partial response in the LEN group was significantly higher than that in the SOR group. Serum thyroglobulin significantly decreased from the beginning of treatment to 1 month later in the LEN group (not in the SOR group). The neutrophil-lymphocyte ratio (NLR) was significantly decreased at 1 month later in both groups. An NLR ≥3 at the start of MKI treatment had a prognostic impact.

CONCLUSION: For RR-DTC, LEN could be more effective than SOR, at l east in the short term. The first-line drug should be selected based on other factors (e.g., adverse events, patient background).

PMID:33622902 | DOI:10.21873/invivo.12350

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

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