tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis

tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis

<i>tmem33</i> is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis, Published online: 13 February 2019; doi:10.1038/s41467-019-08590-7

Calcium signalling downstream of VEGF is essential for VEGF-induced angiogenesis. Here Savage et al. show that Transmembrane Protein 33 (TMEM33) is required for angiogenesis and the endothelial calcium response to VEGF, revealing a function for TMEM33 in multicellular organisms.

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