Stratification of Grade of Spinal Cord Non-Ependymal Gliomas by Magnetic Resonance Imaging.

Stratification of Grade of Spinal Cord Non-Ependymal Gliomas by Magnetic Resonance Imaging.

World Neurosurg. 2019 Feb 08;:

Authors: Zhao B, Zhang C, Zhao X, Yao J, Li J, Ma Y, Shi W, Zheng Z

Abstract
OBJECTIVE: The purpose of this study was to demonstrate the usefulness of conventional magnetic resonance imaging (MRI) in stratification of spinal cord non-ependymal gliomas.
METHODS: Forty-one patients (mean age, 29.9 ± 16.8 years; 27 males) with first-diagnosed spinal cord non-ependymal gliomas underwent conventional MR imaging including T1-weighted (T1W), T2-weighted (T2W) and contrast enhanced T1-weighted (CE-T1W) imaging sequences. The tumors were removed by surgery and processed by histology one week after MR imaging. Patients were divided into low-grade and high-grade groups according to histological findings. The MR imaging features of gliomas including signal-to-noise-ratio (SNR), margins, heterogeneity, edema, enhancement, tumor size, longitudinal location, and presence of syrinx were measured and compared between low-grade and high-grade groups using Chi-square and Mann-Whitney tests.
RESULTS: The SNR of low-grade gliomas on T2W images was significantly higher than that of high-grade gliomas (165.0 ± 108.7 vs. 98.6 ± 44.4, p = 0.016 by Mann-Whitney test). The margins of low-grade gliomas were found to be clearer compared with that of high-grade gliomas (54.5% vs 5.3%, p = 0.001). ROC analysis revealed that the AUC of 1/SNR, margin and the combination of 1/SNR and margin was 0.722 (95%CI, 0.564-0.880), 0.736 (95%CI, 0.578-0.894), and 0.845 (95%CI, 0.717-0.973), respectively. No significant differences were found in the heterogeneity, edema, enhancement level, enhancement SNR, size, longitudinal location, cyst, hemorrhage and intramedullary location between low-grad and high-grade non-ependymal gliomas (all p >0.05).
CONCLUSIONS: The characteristics of signal intensity and margin on T2-weighted imaging are valuable in stratification of spinal cord non-ependymal gliomas.

PMID: 30743029 [PubMed - as supplied by publisher]

from A via a.sfakia on Inoreader http://bit.ly/2SJuMRa