Reversible fold-switching controls the functional cycle of the antitermination factor RfaH

Reversible fold-switching controls the functional cycle of the antitermination factor RfaH

Reversible fold-switching controls the functional cycle of the antitermination factor RfaH, Published online: 11 February 2019; doi:10.1038/s41467-019-08567-6

The antitermination factor RfaH adopts two functional states where its C-terminal domain is folded either as an α-helical hairpin or β-barrel. Here the authors employ solution state NMR measurements to show that the C-terminal domain transforms into the β-barrel only upon binding to the elongation complex and refolds back after dissociation.

from A via a.sfakia on Inoreader https://go.nature.com/2BspKi8