Predictors of epilepsy presentation in unruptured brain arteriovenous malformations: a quantitative evaluation of location and radiomics features on T2 weighted imaging.

Predictors of epilepsy presentation in unruptured brain arteriovenous malformations: a quantitative evaluation of location and radiomics features on T2 weighted imaging.

World Neurosurg. 2019 Feb 13;:

Authors: Zhang Y, Yan P, Liang F, Ma C, Liang S, Jiang C

Abstract
OBJECTIVE: To explore predictors of epilepsy presentation in unruptured bAVMs with quantitative evaluation of location and radiomics features on T2 weighted imaging.
METHODS: This retrospective study identified 117 patients with unruptured bAVMs. Cases were randomly split into training (n=90) and test dataset (n=27). On the training dataset, we applied atlas-based analysis (ABA) to identify epilepsy-susceptible brain regions of bAVMs and then applied radiomics technique to explore shape, intensity and textural features that were correlated with epilepsy presentation. Informative radiomics predictors were selected by Least Absolute Shrinkage and Selection Operator (LASSO) with 3-fold cross-validation. A linear classification score was then constructed, and we tested if we can precisely identify epilepsy-susceptible bAVMs with the location and radiomics predictors.
RESULTS: 2 brain regions and 4 radiomics features were screened out as predictors for epilepsy. The percentage damage of right precentral gyrus (PrCG_R) and right superior longitudinal fasciculus (SLR_R) was associated with epilepsy presentation. The 4 radiomics features were Original_firstorder_Median, Wavelet-LHL_firstorder_InterquartileRange, Wavelet-HHL_firstorder_InterquartileRange and Wavelet-HHH_glrlm_RunVariance. Epileptogenic bAVMs had larger variance of run lengths, larger median value and interquartile range of voxel intensities. On the training dataset, these 6 predictors were able to classify epilepsy-susceptible bAVMs with accuracy at 0.822 and the area under the curve (AUC) was 0.866 (95% CI: 0.791-0.940). On the test dataset, sensitivity, specificity and accuracy of classification reached 0.786, 0.769 and 0.778.
CONCLUSIONS: Epilepsy-susceptible bAVMs had distinct locations and radiomics features on T2 weighted imaging.

PMID: 30771548 [PubMed - as supplied by publisher]

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