Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene, Published online: 07 February 2019; doi:10.1038/s41467-019-08585-4

Insulin-related gene (Insig) negatively regulates hepatic fatty acid synthesis, a process involved in development of non-alcoholic fatty liver disease (NAFLD). Here, the authors show that AMPK activation by metformin promotes Insig phosphorylation, stabilizing it and inhibiting lipogenic gene expression. This is protective against steatosis in diabetic mice.

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