Long non-coding RNA HOXB-AS1 promotes proliferation, migration and invasion of glioblastoma cells via HOXB-AS1/miR-885-3p/HOXB2 axis.

Long non-coding RNA HOXB-AS1 promotes proliferation, migration and invasion of glioblastoma cells via HOXB-AS1/miR-885-3p/HOXB2 axis.

Neoplasma. 2019 Feb 20;:

Authors: Chen X, Li LQ, Qiu X, Wu H

Abstract
Long non-coding RNAs (lncRNAs) have been proven to play important roles in carcinogenesis and development of numerous cancers, but their biological functions in glioblastoma remain largely unknown. In this study, we found that HOXB-AS1 was highly expressed in human glioblastoma tissues and cell lines, and was associated with survival time of patients. Further analysis showed that knockdown of HOXB-AS1 inhibited cell proliferation via inducing S phase cell cycle arrest, and suppressed the migration and invasion ability of cells. Mechanism study revealed that HOXB-AS1 was mainly located in cytoplasm and functioned as competing endogenous RNA via sponging of miR-885-3p. Moreover, inhibition of miR-885-3p antagonized the effects of HOXB-AS1 knockdown and promoted the proliferation, migration and invasion of glioblastoma cells. Finally, we found that sponging of miR-885-3p by HOXB-AS1 could further affect the expression of HOXB2. Taken together, we demonstrated that HOXB-AS1/miR-885-3p/HOXB2 axis could regulate the proliferation, migration and invasion of glioblastoma cells, which could serve as a potential biomarker for the malignancy. Keywords: Glioblastoma, HOXB-AS1, miR-885-3p, proliferation, migration.

PMID: 30784279 [PubMed - as supplied by publisher]

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