Esophageal schwannoma: Case report and epidemiological, clinical, surgical and immunopathological analysis.

Esophageal schwannoma: Case report and epidemiological, clinical, surgical and immunopathological analysis.

Int J Surg Case Rep. 2019 Jan 10;55:69-75

Authors: Souza LCA, Pinto TDA, Cavalcanti HOF, Rezende AR, Nicoletti ALA, Leão CM, Cunha VC

Abstract
INTRODUCTION: Schwannoma is a tumor of the peripheral nervous system originated in the Schwann cells of the neural sheath.
PRESENTATION OF CASE: A 43-years-old male complained of odynophagia, dysphagia and hemoptysis. The upper gastrointestinal endoscopy showed a smooth elevated lesion, 20 cm from the incisor teeth, occupying the entire lumen of the esophagus. The chest computed tomography (CT) scan showed a lesion of 7 cm and superior mediastinal, lower paraesophageal and cardiac enlarged lymph nodes. A posterolateral thoracotomy was performed with total esophagectomy without intraoperative complications. The anatomopathological analysis revealed fusocellular mesenchymal neoplasia of low malignancy potential. The immunohistochemical study showed positivity for S-100 protein and KI67 antibodies and absence of staining for CD117, CD34, ALK protein, SMA and Desmin. Thus, the morphological and immunohistochemical findings pointed to the diagnosis of esophageal Schwannoma.
DISCUSSION: Although rare and indolent, Schwannoma occurs in the peripheral nervous system, being uncommon in the esophagus.
CONCLUSION: The immunohistochemical study is essential for the diagnosis, which is based on the positivity for S-100 protein and absence of staining for CD34 and CD117.

PMID: 30710876 [PubMed - as supplied by publisher]

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