Antioxidant, anti-inflammatory and cytotoxic/antitumoral bioactives from the phylum Basidiomycota and their possible mechanisms of action.

Antioxidant, anti-inflammatory and cytotoxic/antitumoral bioactives from the phylum Basidiomycota and their possible mechanisms of action.

Biomed Pharmacother. 2019 Feb 19;112:108643

Authors: Vieira Gomes DC, de Alencar MVOB, Dos Reis AC, de Lima RMT, de Oliveira Santos JV, da Mata AMOF, Soares Dias AC, da Costa JS, de Medeiros MDGF, Paz MFCJ, Gayoso E Almendra Ibiapina Moreno LC, Castro E Sousa JM, Islam MT, Melo Cavalcante AAC

Abstract
Biologically active compounds from species of the phylum Basidiomycota have been shown a wide range of pharmacological activities and provide a vast reservoir of potential innovational drugs. The aim of this review is to discuss some mechanisms of action involved in antioxidant, anti-inflammatory and cytotoxic/antitumoral activities attributed to the bioactive compounds from species of the phylum Basidiomycota. We show that isolated compounds from extracts, secondary metabolites and polysaccharides that presented antioxidant properties have mechanisms of action involved in the elimination/capture of free radicals and reduction of lipid peroxidation. Also, some bioactives with anti-inflammatory activity were reported to enhance innate and cell-mediated immune responses. Finally, compounds that presented cytotoxic/antitumoral activity induces increased free radical production, collapse of the mitochondrial membrane potential and increased expression of proteins responsible for cell cycle arrest and apoptosis. Investigating the mechanisms of action of biologically active compounds will facilitate further efforts to accelerate the discovery of novel therapeutic strategies.

PMID: 30784926 [PubMed - as supplied by publisher]

from A via a.sfakia on Inoreader https://ift.tt/2GU2pt7