A network-centric approach to drugging TNF-induced NF-κB signaling

A network-centric approach to drugging TNF-induced NF-κB signaling

A network-centric approach to drugging TNF-induced NF-κB signaling, Published online: 26 February 2019; doi:10.1038/s41467-019-08802-0

Chemical perturbation of specific protein–protein interactions is notoriously difficult, yet necessary when complete inhibition of a signalling pathway is detrimental to the cell. Here, the authors use a systems approach and identify two first-in-class small molecules that specifically inhibit TNF-induced NF-κB activation.

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