A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation

A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation

A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation, Published online: 11 February 2019; doi:10.1038/s41467-019-08487-5

Transcription is globally repressed in early stage of embryo development, but a set of genes including pri-miR-430 and zinc finger genes is known to escape the repression. Here the authors image the very first transcriptional activities in the living zebra fish embryo, demonstrating a cell cycle-coordinated polymerase II transcription compartment.

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