The Combination of Benzaldehyde and Nickel‐Catalyzed Photoredox C(sp3)−H Alkylation/Arylation

A combined approach: A simple and general strategy involving the combination of a photo‐organocatalyst (benzaldehyde) and a transition‐metal catalyst (nickel) has been developed for the highly selective photoredox C(sp³)−H alkylation/arylation of ethers. A selective late‐stage modification of (−)‐ambroxide has also been conducted to demonstrate the applicability of the method.

Abstract

Herein we report a highly selective photoredox C(sp³)−H alkylation/arylation of ethers through the combination of a photo‐organocatalyst (benzaldehyde) and a transition‐metal catalyst (nickel). This method provides a simple and general strategy for the C(sp³)−H alkylation/arylation of ethers. A selective late‐stage modification of (−)‐ambroxide has also been conducted to demonstrate the applicability of the method.

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