TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression

TAZ couples Hippo/Wnt signalling and insulin sensitivity through <i>Irs1</i> expression, Published online: 24 January 2019; doi:10.1038/s41467-019-08287-x

Insulin resistance is associated with development of type 2 diabetes. Here the authors show that TAZ interacts with c-Jun and Tead4, inducing expression of the insulin receptor substrate 1 (IRS1) leading to increased glucose uptake in muscle, and that its activity is counteracted by statin administration.

from A via a.sfakia on Inoreader https://go.nature.com/2B10jUN