Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

Optogenetic stimulation of medial prefrontal cortex <i>Drd1</i> neurons produces rapid and long-lasting antidepressant effects, Published online: 15 January 2019; doi:10.1038/s41467-018-08168-9

Ketamine exerts fast-acting anti-depressant responses. Here the authors show that dopamine D1 receptor expressing neurons in the medial prefrontal cortex contribute to these antidepressant-like effects in mice.

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