One‐Dimensional Fe2P Acts as a Fenton Agent in Response to NIR II Light and Ultrasound for Deep Tumor Synergetic Theranostics

Sound and light: Biocompatible 1D ferrous phosphide nanorods (FP NRs) have ultrasound (US) and photothermal (PT)‐enhanced Fenton properties and high photothermal conversion efficiency (56.6 %) in the NIR II window, showing excellent synergistic therapeutic properties. FP NRs can also be used as a photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) agent.

Abstract

The stringent reaction conditions for an effective Fenton reaction (pH range of 3–4) hinders its application in cancer therapy. Therefore, how to improve the efficiency of the Fenton reaction in a tumor site has been the main obstacle in chemodynamic therapy (CDT). Herein, we report biocompatible one‐dimensional (1D) ferrous phosphide nanorods (FP NRs) with ultrasound (US)‐ and photothermal (PT)‐enhanced Fenton properties and excellent photothermal conversion efficiency (56.6 %) in the NIR II window, showing synergistic therapeutic properties. Additionally, the high photothermal conversion efficiency and excellent traverse relaxivity (277.79 mm ⁻¹ s⁻¹) of the FP NRs means they are excellent photoacoustic imaging (PAI) and magnetic resonance imaging (MRI) agents. This is the first report on exploiting the response of metallic phosphides to NIR II laser (1064 nm) and ultrasound to improve the CDT effect with a high therapeutic effect and PA/MR imaging.

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