Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro, Published online: 10 January 2019; doi:10.1038/s41467-018-08003-1

Myocardial tissue undergoes steady functional decline when cultured in vitro. Here, the authors report a protocol for culture of human cardiac slices that allows maintenance of contractility for up to four months, and show that the model is suitable for evaluation of drug safety, as exemplified for drugs interfering with cardiomyocyte repolarization.

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