Identification of first-in-class enzyme involved in childbirth and muscle diseases

According to a Stanford News article, the discovery of the enzyme, called SETD3, solves a 50-year-old mystery of how and why a specific modification (often observed after exercise) to a protein in muscles occurs. The study was published in Nature. The protein, SETD3, adds a molecule called a methyl group to a certain location on a protein — actin — found in muscle fibers. That process is what gives the newly-identified enzyme its classification as a histidine methyltransferase, the firs...

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