Αρχειοθήκη ιστολογίου

Παρασκευή 18 Ιανουαρίου 2019

Enantioselective Aluminum‐Free Alkene Hydroarylations through C−H Activation by a Chiral Nickel/JoSPOphos Manifold

Angewandte Chemie International Edition Enantioselective Aluminum‐Free Alkene Hydroarylations through C−H Activation by a Chiral Nickel/JoSPOphos Manifold

SPO rules: A chiral Ni/SPO regime enabled outstanding levels of enantio‐control in asymmetric C−H alkylations with unactivated alkenes.


Abstract

Highly enantioselective nickel‐catalyzed alkene endo‐hydroarylations were accomplished with full selectivity by organometallic C−H activation. The asymmetric assembly of chiral six‐membered scaffolds proved viable in the absence of pyrophoric organoaluminum reagents within an unprecedented nickel/JoSPOphos manifold.



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Δημοσίευση σχολίου

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

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