Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages

Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages, Published online: 24 January 2019; doi:10.1038/s41467-018-08236-0

Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding profiles.

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