Copper‐Catalyzed Asymmetric Arylation of N‐Heteroaryl Aldimines via an Elementary Step of 1,4‐Insertion

Copper complexes of monodentate phosphoramidites efficiently promote asymmetric arylation of N‐azaaryl aldimines with arylboroxines. DFT calculations and kinetic isotopic experiments support an elementary step of 1,4‐insertion in the reaction pathway, in which an aryl‐copper species adds directly across four atoms C=N‐C=N in N‐azaaryl aldimines.

from A via a.sfakia on Inoreader http://bit.ly/2Crg4Eb