Age-related remodelling of oesophageal epithelia by mutated cancer drivers

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

Age-related remodelling of oesophageal epithelia by mutated cancer drivers, Published online: 02 January 2019; doi:10.1038/s41586-018-0811-x

In physiologically normal epithelia, age-related expansion of clones that carry mutations in NOTCH1 and other driver genes is accelerated by risk factors for developing oesophageal squamous cell carcinoma, such as alcohol consumption or smoking.

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