Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity

Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity, Published online: 18 December 2018; doi:10.1038/s41467-018-07199-6

More than 18 human papillomaviruses (HPV) are associated with cervical cancer, and ideally vaccines should protect from all of them. Here, the authors engineer a triple-type, chimeric HPV vaccine, using loop swapping, that elicits robust neutralizing antibody titers in mice and non-human primates.

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