Modeling genome-wide enzyme evolution predicts strong epistasis underlying catalytic turnover rates

Modeling genome-wide enzyme evolution predicts strong epistasis underlying catalytic turnover rates

Modeling genome-wide enzyme evolution predicts strong epistasis underlying catalytic turnover rates, Published online: 10 December 2018; doi:10.1038/s41467-018-07649-1

The catalytic efficiency of many enzymes is lower than the theoretical maximum. Here, the authors combine genome-scale metabolic modeling with population genetics models to simulate enzyme evolution, and find that strong epistasis limits turnover numbers due to diminishing returns of fitness gains.

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