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Δευτέρα 27 Νοεμβρίου 2017

Training health professionals to recruit into challenging randomized controlled trials improved confidence: the development of the QuinteT RCT Recruitment Training Intervention

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Publication date: Available online 27 November 2017
Source:Journal of Clinical Epidemiology
Author(s): Nicola Mills, Daisy Gaunt, Jane M. Blazeby, Daisy Elliott, Samantha Husbands, Peter Holding, Leila Rooshenas, Marcus Jepson, Bridget Young, Peter Bower, Catrin Tudur Smith, Carrol Gamble, Jenny L. Donovan
ObjectiveTo describe and evaluate a training intervention for recruiting patients to randomized controlled trials (RCTs), particularly for those anticipated to be difficult for recruitment.Study Design and SettingOne of three training workshops were offered to surgeons and one to research nurses. Self-confidence in recruitment was measured through questionnaires before and up to three months after training; perceived impact of training on practice was assessed after. Data were analyzed using two-sample t-tests and supplemented with findings from the content analysis of free text comments.Results67 surgeons and 32 nurses attended. Self-confidence scores for all 10 questions increased after training [range of mean scores before 5.1-6.9 and after 6.9-8.2 (scale 0-10, all 95% CIs are above 0 and all p-values <0.05)]. Awareness of hidden challenges of recruitment following training was high – surgeons' mean score 8.8 (SD 1.2), nurses' 8.4 (SD 1.3) (scale 0-10). 50% (19/38) of surgeons and 40% (10/25) of nurses reported on a 4-point Likert scale that training had made 'a lot' of difference to their RCT discussions. Analysis of free text revealed this was mostly in relation to how to convey equipoise, explain randomization and manage treatment preferences.ConclusionsSurgeons and research nurses reported increased self-confidence in discussing RCTs with patients, a raised awareness of hidden challenges and a positive impact on recruitment practice following QuinteT RCT Recruitment Training. Training will be made more available and evaluated in relation to recruitment rates and informed consent.



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