Executive Summary of the NHLBI Workshop Report: Leveraging Current Scientific Advances to Better Understand Sarcoidosis Variability and Improve Outcomes.

Executive Summary of the NHLBI Workshop Report: Leveraging Current Scientific Advances to Better Understand Sarcoidosis Variability and Improve Outcomes.

Ann Am Thorac Soc. 2017 Oct 19;:

Authors: Maier LA, Crouser ED, Martin WJ, Eu J

Abstract
Sarcoidosis is a systemic granulomatous disease that primarily affects the lung; it is associated with significant disparities, more commonly impacting those in the prime of their lives, age 20-50, with a second peak after age 60, Blacks, and women. However, the burden of disease, the ability to diagnose and prognose organ involvement and course, as well as specific treatment and management options, and disease pathogenesis remain poorly understood. As a result, the National Heart Lung and Blood Institute (NHLBI) undertook a sarcoidosis workshop "Leveraging Current Scientific Advancements to Understand Sarcoidosis Variability and Improve Outcomes" to help address these issues by defining the scientific and clinical priorities to improve sarcoidosis care. The overarching recommendations from this workshop are outlined in the following summary and detailed in the accompanying papers. The recommendations included establishing collaborations and networks to conduct research based on consensus definitions of disease phenotypes and standards of care and to provide clinical outreach to areas with a burden of disease to improve care. These collaborative networks would also serve as the hub to conduct clinical trials of devastating phenotypes (e.g., cardiac, neurologic, and fibrotic disease) not only for treatment but to enhance our understanding of the burden of disease. In addition, the networks would be used to leverage state of the art Omics and systems biology research, as well as other studies to advance understanding of disease pathogenesis, development of biomarkers and therapeutic targets, with a goal to translate this information to improve care to individuals with sarcoidosis.

PMID: 29048937 [PubMed - as supplied by publisher]

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