Estimation of lung shunt fraction from simultaneous fluoroscopic and nuclear images

Radioembolisation with yttrium-90 ( 90 Y) is increasingly used as a treatment of unresectable liver malignancies. For safety, a scout dose of technetium-99m macroaggregated albumin ( 99m Tc-MAA) is used prior to the delivery of the therapeutic activity to mimic the deposition of 90 Y. One-day procedures are currently limited by the lack of nuclear images in the intervention room. To cope with this limitation, an interventional simultaneous fluoroscopic and nuclear imaging device is currently being developed. The purpose of this simulation study was to evaluate the accuracy of estimating the lung shunt fraction (LSF) of the scout dose in the intervention room with this device and compare it against current clinical methods. Methods: A male and female XCAT phantom, both with two respiratory profiles, were used to simulate various LSFs resulting from a scout dose of 150 MBq 99m Tc-MAA. Hybrid images were Monte Carlo simulated for breath-...

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2yjnDMz
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