Chromatin modification: A novel insight into BRAF-independent spontaneous melanoma

Abstract

Chromatin modifying enzymes place and remove chemical groups on histones and DNA in a very dynamic and regulated fashion. Along with impacting the structure of chromatin by altering non-covalent interactions between nucleosomes (1), these epigenetic modifications can more directly regulate DNA-based processes including transcription, and DNA repair and replication. Aberrant activity of chromatin modifying enzymes can have profound consequences that can lead to the initiation and maintenance of various cancers (1).

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