Cells, Vol. 6, Pages 37: Standard Assays for the Study of Autophagy in the Ex Vivo Retina

Cells, Vol. 6, Pages 37: Standard Assays for the Study of Autophagy in the Ex Vivo Retina

Cells doi: 10.3390/cells6040037

Authors: Raquel Gómez-Sintes Beatriz Villarejo-Zori Ana Serrano-Puebla Lorena Esteban-Martínez Elena Sierra-Filardi Ignacio Ramírez-Pardo Natalia Rodríguez-Muela Patricia Boya

Autophagy is a catabolic pathway that mediates the degradation and recycling of intracellular components, and is a key player in a variety of physiological processes in cells and tissues. Recent studies of autophagy in the eye suggest that this pathway is fundamental for the preservation of retinal homeostasis. Given its accessible location outside the brain, the retina is an ideal organ in which to study the central nervous system and a wide range of neuronal processes, from development to neurodegeneration. Here we review several methods used to assess autophagy in the retina in both physiological and pathological conditions.

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