Autoimmune Progesterone Dermatitis Presenting as Stevens-Johnson Syndrome.

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Autoimmune Progesterone Dermatitis Presenting as Stevens-Johnson Syndrome.

Obstet Gynecol. 2017 Oct;130(4):881-884

Authors: Drayer SM, Laufer LR, Farrell ME

Abstract
BACKGROUND: Autoimmune progesterone dermatitis is an uncommon disease presenting with cyclical skin eruptions corresponding with the menstrual cycle luteal phase. Because symptoms are precipitated by rising progesterone levels, treatment relies on hormone suppression.
CASE: A 22-year-old nulligravid woman presented with symptoms mistaken for Stevens-Johnson syndrome. A cyclic recurrence of her symptoms was noted, and the diagnosis of autoimmune progesterone dermatitis was made by an intradermal progesterone challenge. After 48 months, she remained refractory to medical management and definitive surgical treatment with bilateral oophorectomy was performed.
CONCLUSION: Autoimmune progesterone dermatitis is a challenging diagnosis owing to its rarity and variety of clinical presentations. Treatment centers on suppression of endogenous progesterone and avoidance of exogenous triggers. When these modalities fail, surgical management must be undertaken.

PMID: 28885418 [PubMed - indexed for MEDLINE]

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