Study of the sleep quality and psychological state of patients with hepatitis B liver cirrhosis.

Study of the sleep quality and psychological state of patients with hepatitis B liver cirrhosis.

Hepatol Res. 2017 Sep 09;:

Authors: Xiao G, Ye Q, Han T, Yan J, Sun L, Wang F

Abstract
We aimed to investigate the sleep quality, mild hepatic encephalopathy, anxiety and depression in patients with hepatitis B cirrhosis by using a variety of scales and questionnaires. A cohort of 341 patients with hepatitis B liver cirrhosis were categorized by Child-Pugh grading (A, B, and C) in this cross-sectional study. Pittsburgh Sleep Quality Index (PSQI), Number Connection Test-A (NCT-A), and Hospital Anxiety and Depression (HAD) evaluated the questionnaires and statistically analyzed the intrinsic correlation. The control group included 50 healthy individuals. 213/341 patients presented PSQI index>5 points. The PSQI、NCT-A、Anxiety scale (HAD) (a) and depression scale (HAD) (d) of the patients were significantly different. The NCT-A positive patients revealed 214 cases of maybe minimal hepatic encephalopathy (MHE) during a preliminary screening of patients. PSQI score of NCT-A positive patients was significantly elevated as compared to NCT-A negative patients(P<0.001). HAD (a) and HAD (d) were significantly different between the NCT-A positive and the NCT-A negative groups, P=0.002 and P=0.006, respectively. Univariate Pearson's correlation analysis found that NCT-A and HAD (a) were positively correlated with PSQI, P<0.001 and P=0.045, respectively; however, Child-Pugh score and HAD (d) were not correlated with PSQI, P=0.061 and P=0.059, respectively. These results indicated that patients with hepatitis B liver cirrhosis have a disturbed sleep, which might be an MHE symptom, further causing considerable anxiety. Thus, the evaluation of the sleep quality and psychological state of patients with hepatitis B liver cirrhosis necessitates further investigation to guide the positive intervention.

PMID: 28888081 [PubMed - as supplied by publisher]

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