Sleep duration and quality as related to left ventricular structure and function.

Sleep duration and quality as related to left ventricular structure and function.

Psychosom Med. 2017 Sep 13;:

Authors: Lee JH, Park SK, Ryoo JH, Oh CM, Kang JG, Mansur RB, Alfonsi JE, Lee Y, Shin SH, McIntyre RS, Jung JY

Abstract
OBJECTIVE: Inadequate sleep is associated with increased risk of cardiovascular events; however, the associations between sleep duration or quality and cardiac function or structure are not well understood. This cross-sectional study was conducted to investigate to what extent sleep duration and quality are associated with left ventricular (LV) diastolic dysfunction or structural deterioration.
METHODS: A total of 31,598 healthy Korean adults who received echocardiography and completed the Pittsburg Sleep Quality Index were enrolled in this study. Participants were stratified into three groups by self-reported sleep duration (i.e., <7h, 7-9h, >9h) and into two groups by subjective sleep quality. Sleep duration was also assessed as a continuous variable. The odds ratios (ORs) for impaired LV diastolic function, increased relative wall thickness (RWT), and LV hypertrophy (LVH) were compared between groups using multivariable logistic regression analyses.
RESULTS: After adjustment for confounding variables (e.g. age, smoking, body mass index), there was a statistically significant association between short sleep duration (<7h) and greater LVH (fully adjusted OR = 1.32 [95% CI 1.02 - 1.73]). Short sleep duration was also significantly associated with greater LVH (0.87 per hour [95% CI 0.78 - 0.98]) and increased RWT (0.92 [95% CI 0.86 - 0.99]), but there was no significant association between sleep and LV diastolic function. Among individuals with normal sleep duration, poor quality of sleep was not associated with adverse cardiac measures.
CONCLUSIONS: These results indicate that short sleep duration (<7h) is associated with unfavorable LV structural characteristics. The association of insufficient sleep with adverse cardiovascular health outcomes may be mediated in part by adverse changes in cardiac structure and function.

PMID: 28914725 [PubMed - as supplied by publisher]

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