Roles of RNA methylation by means of N6-methyladenosine (m6A) in human cancers

Reversible methylation by means of N6-methyladenosine (m6A) is the most prevalent internal modification in mammalian mRNA. This RNA chemical mark is created by proteins that are m6A "writers" and can be reversed by proteins that are m6A "erasers" (i.e., demethylases). Some other proteins serving as "readers" can recognize m6A-containing mRNA and regulate downstream molecular mechanisms accordingly. Although m6A bases in RNA perform critical functions in important biological processes, their roles in cancer biology and cancer stem cells remain largely unknown.

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