Rab GTPases are switched from their GDP-bound inactive conformation to a GTP-bound active state by guanine nucleotide exchange factors (GEFs). The first putative GEFs isolated for Rabs are RABIF (Rab-interacting factor)/MSS4 (mammalian suppressor of Sec4) and its yeast homolog DSS4 (dominant suppressor of Sec4). However, the biological function and molecular...
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Τρίτη 26 Σεπτεμβρίου 2017
RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis [Cell Biology]
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