Osteonecrosis of the Jaw Unrelated to Radiation or Medications

Recently osteonecrosis of the jaw (ONJ) has seen a sharp rise due to drug-induced causes from both bone modulating therapy and anti-angiogenic medication (medication related osteonecrosis of the jaw – MRONJ) as well has head and neck radiotherapy (osteoradionecrosis – ORN). The pathophysiology1,2 for both differ; however, they appear to share many similarities in their presentation, symptoms and risk factors for their occurrence.

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