Magnetic electrospun short nanofibers wrapped graphene oxide as a promising biomaterials for guiding cellular behavior.

Magnetic electrospun short nanofibers wrapped graphene oxide as a promising biomaterials for guiding cellular behavior.

Mater Sci Eng C Mater Biol Appl. 2017 Dec 01;81:314-320

Authors: Feng ZQ, Shi C, Zhao B, Wang T

Abstract
Magnetic particles show extremely wide application prospects in the biomedical field, particularly in the success of cellular manipulation, drug delivery systems, magnetic hyperthermia and NRI contrast enhancement. Graphene oxide with functional groups has a promising biological effect. In this work, we develop magnetic short-fibers wrapped graphene oxide for guiding cellular behavior with the aid of high-speed shear of nanofibers fabricated through electrospinning technique. The diameter and the length of short-fibers are about 300nm and 80μm, respectively. The short-fibers exhibit superior magnetic properties (saturation magnetization value: 50.33emu/g), which has a strong response appearance to the NdFeB magnet. SEM images and laser confocal images display that there has an extremely tight adhesion between the short-fibers wrapped graphene oxide and cells. The control of cell-fibers structure behavior can be realized by applying external magnet. The results may provide an attractive perspective on the treatment of disease with magnetic field.

PMID: 28887977 [PubMed - in process]

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