Independent self-construal mediates the association between CYP19A1 gene variant and subjective well-being.

Independent self-construal mediates the association between CYP19A1 gene variant and subjective well-being.

Conscious Cogn. 2017 Sep 06;55:205-213

Authors: Yang X, Yang Y, Xue M, Fang P, Shen G, Zhang K, Gao X, Yu R, Gong P

Abstract
Testosterone and estrogen are involved in self-related behavioral dispositions and experiences of subjective well-being. In this study, we investigated to what extent the aromatase (CYP19A1) gene, which encodes an enzyme in converting testosterone into estrogen, contributes to subjective well-being and in another self-related disposition: independent and interdependent self-construal. In study 1, a meta-analysis showed that the GG genotype of CYP19A1 (a G/A substitution at Val80, rs700518) was associated with higher testosterone and lower estradiol. In study 2, an empirical study of individuals with the GG (n=115), AG (n=286) and AA (n=193) genotypes indicated that individuals with the GG genotype exhibited higher independent self-construal and higher subjective well-being. The association between the GG genotype of CYP19A1 Val80 and subjective well-being was mediated by the independent self-construal. Our findings reinforce the idea that personality traits such as independent self-construal explain the link between genetic variant and subjective well-being.

PMID: 28888137 [PubMed - as supplied by publisher]

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