IJMS, Vol. 18, Pages 2033: Spatiotemporal Control of Doxorubicin Delivery from “Stealth-Like” Prodrug Micelles

IJMS, Vol. 18, Pages 2033: Spatiotemporal Control of Doxorubicin Delivery from "Stealth-Like" Prodrug Micelles

International Journal of Molecular Sciences doi: 10.3390/ijms18102033

Authors: Li Kong Dimitrios Poulcharidis Gregory Schneider Frederick Campbell Alexander Kros

In the treatment of cancer, targeting of anticancer drugs to the tumor microenvironment is highly desirable. Not only does this imply accurate tumor targeting but also minimal drug release en route to the tumor and maximal drug release once there. Here we describe high-loading, "stealth-like" doxorubicin micelles as a pro-drug delivery system, which upon light activation, leads to burst-like doxorbicin release. Through this approach, we show precise spatiotemporal control of doxorubicin delivery to cells in vitro.

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