ER stress and distinct outputs of the IRE1{alpha} RNase control proliferation and senescence in response to oncogenic Ras [Cell Biology]

Oncogenic Ras causes proliferation followed by premature senescence in primary cells, an initial barrier to tumor development. The role of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in regulating these two cellular outcomes is poorly understood. During ER stress, the inositol requiring enzyme 1α (IRE1α) endoribonuclease (RNase),...

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