E46K {alpha}-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation [Neuroscience]

α-Synuclein (aSyn) is the main driver of neurodegenerative diseases known as "synucleinopathies," but the mechanisms underlying this toxicity remain poorly understood. To investigate aSyn toxic mechanisms, we have developed a primary neuronal model in which a longitudinal survival analysis can be performed by following the overexpression of fluorescently tagged WT...

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