Clinical study of abnormal vagus nerve tension and basal ganglia cerebral infarction induced paroxysmal atrial fibrillation

Publication date: Available online 14 September 2017
Source:Asian Pacific Journal of Tropical Medicine
Author(s): Wen-Bo Cheng, Dong Li, Qin Yang, Yue-Mei Hou
ObjectiveTo investigate the relationship between basal ganglia cerebral infarction and paroxysmal atrial fibrillation caused by abnormal vagus nerve tension.MethodsA total of 1 483 cases of elder patients with cerebral infarction who received head CT or MRI examination during the period were enrolled, 830 patients were male, 613 patients were female, and the average age was 78 years. These cases were divided into basal infarction ganglia group (n = 1 045) and non-basal ganglia infarction group (n = 438) according to the anatomic site of cerebral infarction. The differences of the incidence of paroxysmal atrial fibrillation (PAF), left atrial diameter and heart rate variability were compared between the two groups.ResultsIn basal ganglia infarction group, the incidence rate of PAF was significantly higher than that of non-basal ganglia infarction group (P < 0.05). The incidence trend of cerebral infarction in basal ganglia was age-related, in the > 79 years basal ganglia cerebral infarction group, the incidence of PAF was significantly higher than that of non-basal ganglia infarction group (P < 0.05). There was no significant difference in the left atrial diameter between the basal ganglia infarction group and non-basal ganglia infarction group. Basal ganglia cerebral infarction patients with high PAF have higher Heart rate variability (HRV) than non-basal ganglia infarction group.ConclusionElderly patients with basal ganglia infarction have high incidence of PAF, cerebral basal ganglia of sympathetic nerve damage and increased vagal tension and cardiac vagal tension are the direct causes of paroxysmal atrial fibrillation. The results indicated that the increased central vagal nerve tension mediated PAF probably is a treatment indication of supplying sympathetic neurotransmitter or cardiac vagal denervation treatment.



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