Casein kinase 1α (CK1α), a component of the β-catenin destruction complex, is a critical regulator of Wnt signaling; its ablation induces both Wnt and p53 activation. To characterize the role of CK1α (encoded by Csnk1a1) in skin physiology, we crossed mice harboring floxed Csnk1a1 with mice expressing K14–Cre–ERT2 to generate...
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Τρίτη 19 Σεπτεμβρίου 2017
CK1{alpha} ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation [Medical Sciences]
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