Biomolecules, Vol. 7, Pages 69: Self-Assembly of Human Serum Albumin: A Simplex Phenomenon

Biomolecules, Vol. 7, Pages 69: Self-Assembly of Human Serum Albumin: A Simplex Phenomenon

Biomolecules doi: 10.3390/biom7030069

Authors: Garima Thakur Kovur Prashanthi Keren Jiang Thomas Thundat

Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics.

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