JCM, Vol. 6, Pages 78: Impact of Larger Sputum Volume on Xpert® MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis

JCM, Vol. 6, Pages 78: Impact of Larger Sputum Volume on Xpert® MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis

Journal of Clinical Medicine doi: 10.3390/jcm6080078

Authors: Sharlaa Badal-Faesen Cynthia Firnhaber Michelle Kendall Xingye Wu Beatriz Grinsztejn Rodrigo Escada Michel Fernandez Evelyn Hogg Ian Sanne Pamela Johnson David Alland Gerald Mazurek Debra Benator Anne Luetkemeyer the AIDS Clinical Trials Group A5295 Tuberculosis Trials Consortium Study 34 Teams

As a strategy to improve the sensitivity of nucleic acid-based testing in acid-fast bacilli (AFB) negative samples, larger volumes of sputum (5–10 mL) were tested with Xpert® MTB/RIF from 176 individuals with smear-negative sputum undergoing tuberculosis evaluation. Despite larger volumes, this strategy had a suboptimal sensitivity of 50% (4/8).

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