IJMS, Vol. 18, Pages 1684: Mechanosensitive miRNAs and Bone Formation

IJMS, Vol. 18, Pages 1684: Mechanosensitive miRNAs and Bone Formation

International Journal of Molecular Sciences doi: 10.3390/ijms18081684

Authors: Zhihao Chen Yan Zhang Chao Liang Lei Chen Ge Zhang Airong Qian

Mechanical stimuli are required for the maintenance of skeletal integrity and bone mass. An increasing amount of evidence indicates that multiple regulators (e.g., hormone, cytoskeleton proteins and signaling pathways) are involved in the mechanical stimuli modulating the activities of osteogenic cells and the process of bone formation. Significantly, recent studies have showed that several microRNAs (miRNAs) were sensitive to various mechanical stimuli and played a crucial role in osteogenic differentiation and bone formation. However, the functional roles and further mechanisms of mechanosensitive miRNAs in bone formation are not yet completely understood. This review highlights the roles of mechanosensitive miRNAs in osteogenic differentiation and bone formation and underlines their potential therapeutic application for bone loss induced by the altering of mechanical stimuli.

from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2vnGLbc
via IFTTT