Cryoelectrolysis; an acute case study in the pig liver

Publication date: Available online 3 August 2017
Source:Cryobiology
Author(s): Franco Lugnani, Enric Gunther, Pedro Torrecillas, Carlos Galacho, Adolfo Jiménez Garrido, Paul Mikus, Nina Klein, Michael K. Stehling, Matteo Macchioro, Liel Rubinsky, Narayan Raju, Boris Rubinsky
We report results from an acute, single case study in the pig liver on the effects of a tissue ablation protocol (we named cryoelectrolysis) in which 10 min of cryosurgery, with a commercial cryosurgical probe, are delivered after 10 min of electrolysis generated by a current of about 60 mA. The histological appearance of tissue treated with cryoelectrolysis is compared with the appearance of tissue treated with 10 min of cryosurgery alone and with 10 min of electrolysis alone. Histology done after 3 h survival shows that the mixed rim of live and dead cells found around the ablated lesion in both cryosurgery and electrolytic ablation is replaced by a sharp margin between life and dead cells in cryoelectrolysis. The appearance of the dead cells in each, cryoelectrolysis, cryosurgery and electrolytic ablation is different. Obviously, this is an acute study and the results are only relevant to the conditions of this study. There is no doubt that additional acute and chronic studies are needed to strengthen and expand the findings of this study.



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